H3B-6527
Cat. No.：YN440014
CAS No. ：1702259-66-2
规格
价格(RMB)
库存
| 产品名称: | H3B-6527 |
| CAS No.: | 1702259-66-2 |
| Chemical Name: | N-[2-[[6-[[[(2,6-dichloro-3,5-dimethoxyphenyl)amino]carbonyl]methylamino]-4-pyrimidinyl]amino]-5-(4-ethyl-1-piperazinyl)phenyl]-2-propenamide |
| Synonyms: | H3B-6527;N-(2-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-yl)phenyl)acrylamide;4HTE364XIK;N-[2-[[6-[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl-methylamino]pyrimidin-4-yl]amino]-5-(4-ethylpiperazin- |
| 分子量: | 629.54 |
| 分子式: | C₂₉H₃₄Cl₂N₈O₄ |
| SMILES: | C=CC(NC1=CC(N2CCN(CC)CC2)=CC=C1NC3=NC=NC(N(C(NC4=C(Cl)C(OC)=CC(OC)=C4Cl)=O)C)=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | H3B-6527 是一种具有口服活性的，高选择性和共价FGFR4抑制剂，IC50<1.2 nM。H3B-6527 抑制 FGFR1-3，IC50分别为 320、1290 和 1060 nM。H3B-6527 具有良好的抗癌活性。 |
| IC50和靶点: | |
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Joshi, J.J., Coffey, H., Corcoran, E., et al.H3B-6527 is a potent and selective inhibitor of FGFR4 in FGF19-driven hepatocellular carcinomaCancer Res.77(24),6999-7013(2017)
