Futibatinib
Cat. No.：YN440022
CAS No. ：1448169-71-8
规格
价格(RMB)
库存
| 产品名称: | Futibatinib |
| CAS No.: | 1448169-71-8 |
| Chemical Name: | 1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidinyl]-2-propen-1-one |
| Synonyms: | TAS-120 |
| 分子量: | 418.45 |
| 分子式: | C₂₂H₂₂N₆O₃ |
| SMILES: | O=C(C=C)N(C1)CC[C@@H]1N(N=C2C#CC3=CC(OC)=CC(OC)=C3)C4=C2C(N)=NC=N4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Futibatinib (TAS-120) 是一种口服生物利用度高、选择性强、不可逆的FGFR抑制剂，对 FGFR 1-4 的 4 个亚型的IC50分别为 3.9、1.3、1.6 和 8.3 nM。Futibatinib 抑制突变型和野生型 FGFR2，且 IC50相似 (wild-type FGFR2=0.9 nM; V5651=1-3 nM; N550H=3.6 nM; E566G=2.4 nM)。 |
| IC50和靶点: | [{name:"FGFR1:3.9 nM (IC50)"},{name: "FGFR2:1.3 nM (IC50)"},{name: "FGFR3:1.6 nM (IC50)"},{name: "FGFR4:8.3 nM (IC50)"},{name: "wild-type FGFR2:0.3 nM (IC50)"},{name: "FGFR2 V5651:1-3 nM (IC50)"},{name: "FGFR2 N550H:3.6 nM (IC50)"},{name: "FGFR2 E566G:2.4 nM (IC50)"}] |
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Ochiiwa, H., Fujita, H., Itoh, K., et al.Abstract A270: TAS-120, a highly potent andselective irreversible FGFR inhibitor, is effective in tumors harboring various FGFR gene abnormalitiesMol. Cancer Ther.12(11),(2013)
