PD-166866
Cat. No.：YN440029
CAS No. ：192705-79-6
规格
价格(RMB)
库存
| 产品名称: | PD-166866 |
| CAS No.: | 192705-79-6 |
| Chemical Name: | N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-urea |
| Synonyms: | PD166866 |
| 分子量: | 396.44 |
| 分子式: | C₂₀H₂₄N₆O₃ |
| SMILES: | O=C(NC(C)(C)C)NC1=NC2=NC(N)=NC=C2C=C1C3=CC(OC)=CC(OC)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD166866是选择性的FGFR1酪氨酸激酶抑制剂，IC50值为52.4 nM。 |
| IC50和靶点: | [{name:"FGFR1:52.4 nM (IC50)"}] |
| In Vitro: | |
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| Solvent & Solubility: |
Panek, R.L., Lu, G.H., Dahring, T.K., et al.In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinaseJ. Pharmacol. Exp. Ther.286(1),569-577(1998)
Fischer, H., Taylor, N., Allerstorfer, S., et al.Fibroblast growth factor receptor-mediated signals contribute to the malignant phenotype of non-small cell lung cancer cells: Therapeutic implications and synergism with epidermal growth factor receptor inhibitionMol. Cancer. Ther.7(10),3408-3419(2008)
