Roblitinib
Cat. No.：YN440037
CAS No. ：1708971-55-4
规格
价格(RMB)
库存
| 产品名称: | Roblitinib |
| CAS No.: | 1708971-55-4 |
| Chemical Name: | N-[5-cyano-4-[(2-methoxyethyl)amino]-2-pyridinyl]-7-formyl-3,4-dihydro-6-[(4-methyl-2-oxo-1-piperazinyl)methyl]-1,8-naphthyridine-1(2H)-carboxamide |
| Synonyms: | FGF-401 |
| 分子量: | 506.56 |
| 分子式: | C₂₅H₃₀N₈O₄ |
| SMILES: | CN1CC(N(CC2=CC(CCCN3C(NC4=CC(NCCOC)=C(C#N)C=N4)=O)=C3N=C2C=O)CC1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Roblitinib (FGF-401) 是一种有效的，选择性的FGFR4抑制剂，IC50为 1.9 nM。Roblitinib 有抗癌活性。 |
| IC50和靶点: | [{name:"FGFR4:1.9 nM (IC50)"},{name: "FGFR1:>10 μM (IC50)"},{name: "FGFR2:>10 μM (IC50)"},{name: "FGFR3:>10 μM (IC50)"},{name: "rat FGFR4:>10 μM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Buschmann, N., Fairhurst, R.A., Furet, P., et al.Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors,(2015)
Schadt, H.S., Wolf, A., Mahl, J.A., et al.Bile acid sequestration by cholestyramine mitigates FGFR4 inhibition-induced ALT elevationToxicol. Sci.163(1),265-278(2018)
