SU 5402
Cat. No.：YN440091
CAS No. ：215543-92-3
规格
价格(RMB)
库存
| 产品名称: | SU 5402 |
| CAS No.: | 215543-92-3 |
| Chemical Name: | 2-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid |
| Synonyms: | SU5402 |
| 分子量: | 296.32 |
| 分子式: | C₁₇H₁₆N₂O₃ |
| SMILES: | O=C(CCC1=C(NC=C1C)/C=C2C(NC3=C\2C=CC=C3)=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SU 5402 是一种有效的多靶点受体酪氨酸激酶抑制剂，作用于VEGFR2，FGFR1和PDGFRβ，IC50分别为 20 nM，30 nM 和 510 nM。 |
| IC50和靶点: | [{name:"VEGFR2:20 nM (IC50)"},{name: "FGFR1:30 nM (IC50)"},{name: "PDGFRβ:510 nM (IC50)"}] |
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| Solvent & Solubility: |
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Heryanto, B., Lipson, K.E., and Rogers, P.A.W.Effect of angiogenesis inhibitors on oestrogen-mediated endometrial endothelial cell proliferation in the ovariectomized mouseReproduction125,337-346(2003)
Ying, Q.L., Wray, J., Nichols, J., et al.The ground state of embryonic stem cell self-renewalNature453,519-524(2008)
Hasse, C., Holz, O., Lange, E., et al.FGFR-ERK signaling is an essential component of tissue separationDev. Biol.395(1),154-166(2014)
Kachel, P., Trojanowicz, B., Sekulla, C., et al.Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase A by fibroblast growth factor receptor 1 in benign and malignant thyroid tissueBMC Cancer15:140,(2015)
