Pemigatinib
Cat. No.：YN440123
CAS No. ：1513857-77-6
规格
价格(RMB)
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| 产品名称: | Pemigatinib |
| CAS No.: | 1513857-77-6 |
| Chemical Name: | 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-8-(4-morpholinylmethyl)-2H-pyrrolo[3′,2′:5,6]pyrido[4,3-d]pyrimidin-2-one |
| Synonyms: | INCB054828 |
| 分子量: | 487.50 |
| 分子式: | C₂₄H₂₇F₂N₅O₄ |
| SMILES: | CCN(C(N(C(C(F)=C(OC)C=C1OC)=C1F)C2)=O)C(C2=CN3)=C4C3=NC(CN5CCOCC5)=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pemigatinib (INCB054828) 是一种具有口服活性的，选择性FGFR抑制剂，对于 FGFR1，FGFR2，FGFR3，FGFR4 的IC50分别为 0.4 nM，0.5 nM，1.2 nM，30 nM。Pemigatinib 有用于胆管癌的潜力。 |
| IC50和靶点: | [{name:"FGFR1:0.4 nM (IC50)"},{name: "FGFR2:0.5 nM (IC50)"},{name: "FGFR3:1.2 nM (IC50)"},{name: "FGFR4:30 nM (IC50)"}] |
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Liu, P.C.C., Koblish, H., Wu, L., et al.INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor modelsPLoS One15(4),e0231877(2020)
