CP-547632
Cat. No.：YN440261
CAS No. ：252003-65-9
规格
价格(RMB)
库存
| 产品名称: | CP-547632 |
| CAS No.: | 252003-65-9 |
| Chemical Name: | 3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-4-isothiazolecarboxamide |
| Synonyms: | CP547632 |
| 分子量: | 532.40 |
| 分子式: | C₂₀H₂₄BrF₂N₅O₃S |
| SMILES: | O=C(NC1=C(C(N)=O)C(OCC2=C(F)C=C(Br)C=C2F)=NS1)NCCCCN3CCCC3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CP-547632 是一种口服有效的，ATP 竞争性的VEGFR-2和FGF激酶抑制剂，IC50分别为 11 nM 和 9 nM。CP-547632 对 VEGFR2 和 bFGF 的选择性高于 EGFR，PDGFRβ 和相关的酪氨酸激酶 (TKs)。CP-547632 具有抗肿瘤作用。 |
| IC50和靶点: | [{name:"VEGFR-2:11 nM (IC50)"},{name: "FGFR:9 nM (IC50)"}] |
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Beebe, J.S., Jani, J.P., Knauth, E., et al.Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapyCancer Res.63(21),7301-7309(2003)
