LY2874455
Cat. No.：YN440263
CAS No. ：1254473-64-7
规格
价格(RMB)
库存
| 产品名称: | LY2874455 |
| CAS No.: | 1254473-64-7 |
| Chemical Name: | 4-[(1E)-2-[5-[(1R)-1-(3,5-dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]-1H-pyrazole-1-ethanol |
| Synonyms: | LY-2874455,LY 2874455 |
| 分子量: | 444.31 |
| 分子式: | C₂₁H₁₉Cl₂N₅O₂ |
| SMILES: | ClC1=CN=CC(Cl)=C1[C@@H](C)OC2=CC=C(NN=C3/C=C/C4=CN(CCO)N=C4)C3=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY2874455 是一种pan-FGFR抑制剂。LY2874455 抑制FGFR1，2，3和4，IC50分别为 2.8，2.6，6.4 和 6 nM。 |
| IC50和靶点: | [{name:"FGFR1:2.8 nM (IC50)"},{name: "FGFR2:2.6 nM (IC50)"},{name: "FGFR3:6.4 nM (IC50)"},{name: "FGFR4:6 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Zhao, G., Li, W.-y., Chen, D., et al.A novel, selective inhibitor of fibroblast growth factor receptors that shows a potent broad spectrum of antitumor activity in several tumor xenograft modelsMol. Cancer Ther.10(11),2200-2210(2011)
