Infigratinib
Cat. No.：YN440265
CAS No. ：872511-34-7
规格
价格(RMB)
库存
| 产品名称: | Infigratinib |
| CAS No.: | 872511-34-7 |
| Chemical Name: | N'-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[6-[[4-(4-ethyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-N-methyl-urea |
| Synonyms: | BGJ-398; NVP-BGJ398 |
| 分子量: | 560.48 |
| 分子式: | C₂₆H₃₁Cl₂N₇O₃ |
| SMILES: | ClC1=C(C(Cl)=C(C=C1OC)OC)NC(N(C2=CC(NC3=CC=C(C=C3)N4CCN(CC4)CC)=NC=N2)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Infigratinib (BGJ-398; NVP-BGJ398) 是FGFR家族的有效抑制剂，抑制FGFR1，FGFR2，FGFR3和FGFR4的IC50分别为 0.9 nM，1.4 nM，1 nM，60 nM。 |
| IC50和靶点: | [{name:"FGFR1:0.9 nM (IC50)"},{name: "FGFR2:1.4 nM (IC50)"},{name: "FGFR3:1 nM (IC50)"},{name: "FGFR4:60 nM (IC50)"}] |
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| Solvent & Solubility: |
Guagnano, V., Furet, P., Spanka, C., et al.Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinaseJ. Med. Chem.54(20),7066-7083(2011)
Hagel, M., Miduturu, C., Sheets, M., et al.First selective small molecule inhibitor of FGFR4 for the treatment of hepatocellular carcinomas with an activated FGFR4 signaling pathwayCancer Discov.5(4),424-437(2015)
