BO-264
Cat. No.:YN440281
产品名称: | BO-264 |
CAS No.: | 2408648-20-2 |
Chemical Name: | N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)-4-pyrimidinamine |
Synonyms: | |
分子量: | 353.38 |
分子式: | C₁₈H₁₉N₅O₃ |
SMILES: | COC1=CC=C(C2=NOC(NC3=NC(N4CCOCC4)=NC=C3)=C2)C=C1 |
存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
运输: | Room temperature in continental US; may vary elsewhere. |
产品描述: | BO-264 是一种高效,口服活性的转化酸性卷曲螺旋 3 (TACC3) 抑制剂,IC50为 188 nM,Kd为 1.5 nM。BO-264 特异性阻断FGFR3-TACC3融合蛋白的功能。BO-264 诱导纺锤体检查点依赖的有丝分裂阻滞,DNA 损伤和细胞凋亡 (apoptosis)。BO-264 具有广谱抗肿瘤活性。 |
IC50和靶点: | |
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Akbulut, O., Lengerli, D., Saatci, O., et al.A highly potent TACC3 inhibitor as a novel anticancer drug candidateMol. Cancer Ther.19(6),1243-1254(2020)