FIIN-2
Cat. No.：YN440377
CAS No. ：1633044-56-0
规格
价格(RMB)
库存
| 产品名称: | FIIN-2 |
| CAS No.: | 1633044-56-0 |
| Chemical Name: | N-[4-[[3-(3,5-dimethoxyphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-oxopyrimido[4,5-d]pyrimidin-1(2H)-yl]methyl]phenyl]-2-propenamide |
| Synonyms: | FIIN-2;N-(4-((3-(3,5-Dimethoxyphenyl)-7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide;FIIN2;BCP14779;BDBM50232829;s7714;A12357;N-(4-{[3-(3,5-dimethoxyphenyl)-7-{[4-(4-methylpiperazin- |
| 分子量: | 634.73 |
| 分子式: | C₃₅H₃₈N₈O₄ |
| SMILES: | C=CC(NC1=CC=C(CN(C2=NC(NC3=CC=C(N4CCN(C)CC4)C=C3)=NC=C2CN5C6=CC(OC)=CC(OC)=C6)C5=O)C=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FIIN-2 是FGFR的不可逆抑制剂，对FGFR1，FGFR2，FGFR3和FGFR4的IC50值分别为3.1，4.3，27和45 nM。 |
| IC50和靶点: | [{name:"FGFR1:3.1 nM (IC50)"},{name: "FGFR2:4.3 nM (IC50)"},{name: "FGFR3:27 nM (IC50)"},{name: "FGFR4:45 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Tan, L., Wang, J., Tanizaki, J., et al.Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitorsProc. Natl. Acad. Sci. USA111(45),E4869-E4877(2014)
