CH5183284
Cat. No.：YN440395
CAS No. ：1265229-25-1
规格
价格(RMB)
库存
| 产品名称: | CH5183284 |
| CAS No.: | 1265229-25-1 |
| Chemical Name: | [5-amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl]-1H-indol-2-yl-methanone |
| Synonyms: | Debio 1347 |
| 分子量: | 356.38 |
| 分子式: | C₂₀H₁₆N₆O |
| SMILES: | O=C(C1=C(N)N(C2=CC=C3N=C(C)NC3=C2)N=C1)C(N4)=CC5=C4C=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CH5183284 (Debio 1347) 是口服可用，选择性的FGFR抑制剂，抑制FGFR1，FGFR2和 FGFR3的IC50值分别为9.3，7.6，22 and 290 nM。 |
| IC50和靶点: | [{name:"FGFR1:9.3 nM (IC50)"},{name: "FGFR2:7.6 nM (IC50)"},{name: "FGFR3:22 nM (IC50)"},{name: "FGFR4:290 nM (IC50)"}] |
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| Solvent & Solubility: |
Nakanishi, Y., Akiyama, N., Tsukaguchi, T., et al.The fibroblast growth factor receptor genetic status as a potential predictor of the sensitivity to CH5183284/Debio 1347, a novel selective FGFR inhibitorMol. Cancer Ther.13(11),2547-2558(2014)
