Derazantinib
Cat. No.：YN440396
CAS No. ：1234356-69-4
规格
价格(RMB)
库存
| 产品名称: | Derazantinib |
| CAS No.: | 1234356-69-4 |
| Chemical Name: | (6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-benzo[h]quinazolin-2-amine |
| Synonyms: | ARQ-087 |
| 分子量: | 468.57 |
| 分子式: | C₂₉H₂₉FN₄O |
| SMILES: | COCCNCCC1=CC(NC2=NC=C3C[C@@H](C4=CC=CC=C4F)C5=CC=CC=C5C3=N2)=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Derazantinib (ARQ-087) 是ATP竞争型的酪氨酸激酶抑制剂；抑制软骨细胞FGFR1-3的IC50值分别为4.5，1.8 和4.5 nM。 |
| IC50和靶点: | [{name:"FGFR1:4.5 nM (IC50)"},{name: "FGFR2:1.8 nM (IC50)"},{name: "FGFR3:4.5 nM (IC50)"}] |
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| Solvent & Solubility: |
Hall, T.G., Yu, Y., Eathiraj, S., et al.Preclinical activity of ARQ 087, a novel inhibitor targeting FGFR dysregulationPLoS One11(9),e0162594(2016)
