FKBP12 PROTAC dTAG-13
Cat. No.：YN330142
| 产品名称: | FKBP12 PROTAC dTAG-13 |
| CAS No.: | 2064175-41-1 |
| Chemical Name: | (2S)-2-Piperidinecarboxylic Acid 1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl Ester |
| Synonyms: | dTAG-13 |
| 分子量: | 1049.17 |
| 分子式: | C₅₇H₆₈N₄O₁₅ |
| SMILES: | COC1=CC=C(CC[C@H](C2=C(OCC(NCCCCCCOC3=CC=CC4=C3C(N(C5CCC(NC5=O)=O)C4=O)=O)=O)C=CC=C2)OC([C@@H]6CCCCN6C([C@@H](CC)C7=CC(OC)=C(OC)C(OC)=C7)=O)=O)C=C1OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FKBP12 PROTAC dTAG-13 (dTAG-13) 是一种基于 PROTAC 的双功能降解剂。FKBP12 PROTAC dTAG-13 (dTAG-13) 既是一种FKBP12F36V的降解剂，又是一种选择性的 BETBRD4降解剂，FKBP12 PROTAC dTAG-13 (dTAG-13) 通过将 BET 溴结构域桥接至 E3 泛素连接酶 (cereblon; CRBN) 而形成降解剂。 |
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| Solvent & Solubility: |
Hai-Tsang Huang., eLife, 1-29, (2017)
