SLF
Cat. No.：YN330145
CAS No. ：195513-96-3
| 产品名称: | SLF |
| CAS No.: | 195513-96-3 |
| Chemical Name: | 1-(3,3-dimethyl-1,2-dioxopentyl)-(2S)-2-piperidinecarboxylic acid, (1R)-1-(3-aminophenyl)-3-(3,4-dimethoxyphenyl)propyl ester |
| Synonyms: | |
| 分子量: | 524.65 |
| 分子式: | C₃₀H₄₀N₂O₆ |
| SMILES: | O=C([C@H]1N(C(C(C(C)(C)CC)=O)=O)CCCC1)O[C@@H](C2=CC=CC(N)=C2)CCC3=CC=C(OC)C(OC)=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SLF 是 FK506 结合蛋白 (FKBP) 的合成配体，对FKBP51的亲和力为 3.1 μM，对FKBP12的IC50为 0.22 μM，可用于合成 PROTAC 分子。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Dumont, F.J.FK506, An immunosuppressant targeting calcineurin functionCurr. Med. Chem.7(7),731-748(2000)
Braun, P.D., Barglow, K.T., Lin, Y.M., et al.A bifunctional molecule that displays context-dependent cellular activityJ. Am. Chem. Soc.125,7575-7580(2003)
Amara, J.F., Clackson, T., Rivera, V.M., et al.A versatile synthetic dimerizer for the regulation of protein-protein interactionsProc. Natl. Acad. Sci. USA94,10618-10623(1997)
