FKBP12 PROTAC dTAG-7
Cat. No.：YN330190
| 产品名称: | FKBP12 PROTAC dTAG-7 |
| CAS No.: | 2064175-32-0 |
| Chemical Name: | (2S)-2-Piperidinecarboxylic Acid 1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-, (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[[19-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-2,18-dioxo-7,10,13-trioxa-3,17-diazanonadec-1-yl]oxy]phenyl] |
| Synonyms: | dTAG-7 |
| 分子量: | 1210.32 |
| 分子式: | C₆₃H₇₉N₅O₁₉ |
| SMILES: | O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC=C3OCC(NCCCOCCOCCOCCCNC(COC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)=O)CCC7=CC=C(OC)C(OC)=C7 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | FKBP12 PROTAC dTAG-7 (dTAG-7) 是一种双功能降解剂。FKBP12 PROTAC dTAG-7 (dTAG-7) 既是一种FKBP12F36V的降解剂，又是一种选择性的 BETBRD4降解剂，FKBP12 PROTAC dTAG-7 (dTAG-7) 通过将 BET 溴结构域桥接至 E3 泛素连接酶 (cereblon; CRBN) 而形成降解剂。 |
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| Solvent & Solubility: |
Hai-Tsang Huang., eLife, 1-29, (2017)
