Ascomycin
Cat. No.：YN330248
CAS No. ：104987-12-4
| 产品名称: | Ascomycin |
| CAS No.: | 104987-12-4 |
| Chemical Name: | (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-py |
| Synonyms: | 子囊霉素; Immunomycin; FR-900520; FK520 |
| 分子量: | 792.01 |
| 分子式: | C₄₃H₆₉NO₁₂ |
| SMILES: | O=C([C@@](CCCC1)([H])N1C(C([C@@]2(O)[C@H](C)C[C@H](OC)[C@@](O2)([H])[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H]3CC)=O)=O)O[C@H](/C(C)=C/[C@H]4C[C@@H](OC)[C@H](O)CC4)[C@H](C)[C@@H](O)CC3=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ascomycin(Immunomycin, FR-900520, FK520)是tacrolimus (FK506)的类似物，具有很强的免疫抑制剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Mrowietz, U.Macrolide immunosuppressantsEur. J. Dermatol.9(5),346-351(1999)
Andexer, J.N., Kendrew, S.G., Nur-e-Alam, M., et al.Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismateProc. Natl. Acad. Sci. USA108(12),4776-4781(2011)
Monaghan, P., Fardis, M., Revill, W.P., et al.Antimalarial effects of macrolactones related to FK520 (ascomycin) are independent of the immunosuppressive properties of the compoundsJ. Infect. Dis.191(8),1342-1349(2005)
