AP20187
Cat. No.：YN330279
CAS No. ：195514-80-8
| 产品名称: | AP20187 |
| CAS No.: | 195514-80-8 |
| Chemical Name: | 2-piperidinecarboxylic acid, (2S,2′S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2,2′-[[2-[(dimethylamino)methyl]-1,3-propanediyl]bis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] ester |
| Synonyms: | B/B Homodimerizer |
| 分子量: | 1482.75 |
| 分子式: | C₈₂H₁₀₇N₅O₂₀ |
| SMILES: | COC1=C(OC)C=C(CC[C@H](C2=CC=CC(OCC(NCC(CN(C)C)CNC(COC3=CC=CC([C@H](OC([C@H]4N(C([C@@H](CC)C5=CC(OC)=C(OC)C(OC)=C5)=O)CCCC4)=O)CCC6=CC(OC)=C(OC)C=C6)=C3)=O)=O)=C2)OC([C@@H]7CCCCN7C([C@H](C8=CC(OC)=C(OC)C(OC)=C8)CC)=O)=O)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AP20187 (B/B Homodimerizer) 是一种细胞渗透性分子，使 FK506 结合蛋白 (FKBP) 二聚化，启动生物信号传导级联反应和基因表达，或破坏蛋白-蛋白之间相互作用。 |
| IC50和靶点: | |
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Shariat, S.F., Desai, S., Song, W., et al.Adenovirus-mediated transfer of inducible caspases: A novel "death switch" gene therapeutic approach to prostate cancerCancer Res.61(6),2562-2571(2001)
Lin, W., Lin, Y., Li, J., et al.Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitisJ. Neurosci.33(14),5980-5991(2013)
Baker, D.J., Childs, B.G., Durik, M., et al.Naturally occurring p16Ink4a-positive cells shorten healthy lifespanNature530(7589),184-189(2016)
