5'-Fluoroindirubinoxime
Cat. No.：YN440086
CAS No. ：861214-33-7
规格
价格(RMB)
库存
| 产品名称: | 5'-Fluoroindirubinoxime |
| CAS No.: | 861214-33-7 |
| Chemical Name: | 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-5-fluoro-1,3-dihydro-2H-indol-2-one |
| Synonyms: | 5'-FIO |
| 分子量: | 295.27 |
| 分子式: | C₁₆H₁₀FN₃O₂ |
| SMILES: | O=C1NC2=C(C=C(F)C=C2)/C1=C3NC4=C(C=CC=C4)C\3=N/O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 5'-Fluoroindirubinoxime (compound 13) 是Indirubin (HY-N0117) 的衍生物，是FLT3的抑制剂，其IC50值为15 nM。 |
| IC50和靶点: | |
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Choi, S.-J., Lee, J.-E., Jeong, S.-Y., et al.5,5'-substituted indirubin-3'-oxime derivatives as potent cyclin-dependent kinase inhibitors with anticancer activityJ. Med. Chem.53(9),3696-3706(2010)
Jung, M.E., Byun, B.J., Kim, H.-M., et al.Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screeningBioorg. Med. Chem. Lett.26(11),2719-2723(2016)
Moon, M.J., Lee, S.K., Lee, J.-W., et al.Synthesis and structure-activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activitiesBioorg. Med. Chem.14(1),237-246(2006)
Kim, S.-A., Kim, Y.-C., Kim, S.-W., et al.Antitumor activity of novel indirubin derivatives in rat tumor modelClin. Cancer Res.13(1),253-259(2007)
Krivogorsky, B., Grundt, P., Yolken, R., et al.Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogsAntimicrob. Agents Chemother.52(12),4466-4469(2008)
