G-749
Cat. No.：YN440205
CAS No. ：1457983-28-6
规格
价格(RMB)
库存
| 产品名称: | G-749 |
| CAS No.: | 1457983-28-6 |
| Chemical Name: | 8-bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]-pyrido[4,3-d]pyrimidin-5(6H)-one |
| Synonyms: | G749 |
| 分子量: | 521.41 |
| 分子式: | C₂₅H₂₅BrN₆O₂ |
| SMILES: | O=C1C2=C(N=C(NC3CCN(C)CC3)N=C2NC4=CC=C(OC5=CC=CC=C5)C=C4)C(Br)=CN1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | G-749 是一种高效的, ATP 竞争性的FLT3抑制剂，对 FLT3WT和 FLT3D835Y作用的IC50值分别为 0.4 nM 和 0.6 nM。G-749 可用于急性髓系白血病 (AML) 的耐药研究。 |
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Lee, H.K., Kim, H.W., Lee, I.Y., et al.G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemiaBlood123(14),2209-2219(2014)
