UNC2025
Cat. No.：YN440206
CAS No. ：1429881-91-3
规格
价格(RMB)
库存
| 产品名称: | UNC2025 |
| CAS No.: | 1429881-91-3 |
| Chemical Name: | trans-4-[2-(butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclohexanol |
| Synonyms: | UNC 2025,mrx-6313,UNC-2025 |
| 分子量: | 476.66 |
| 分子式: | C₂₈H₄₀N₆O |
| SMILES: | CN1CCN(CC2=CC=C(C3=CN([C@@H]4CC[C@@H](O)CC4)C5=NC(NCCCC)=NC=C53)C=C2)CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | UNC2025 是一种强效、高口服活性的Mer/Flt3抑制剂，IC50值分别为 0.74 nM 和 0.8 nM。UNC2025 对MERTK 的选择性是 Axl 的 45 倍 (IC50=122 nM;Ki=13.3 nM)。UNC2025 具有良好的 PK 特性，可用于急性白血病的研究。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Zhang, W., DeRychere, D., Hunter, D., et al.UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitorJ. Med. Chem.57(16),7031-7041(2014)
