TCS 359
Cat. No.：YN440297
CAS No. ：301305-73-7
规格
价格(RMB)
库存
| 产品名称: | TCS 359 |
| CAS No.: | 301305-73-7 |
| Chemical Name: | 2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxamide |
| Synonyms: | FLT3 Inhibitor |
| 分子量: | 360.43 |
| 分子式: | C₁₈H₂₀N₂O₄S |
| SMILES: | O=C(C1=C(NC(C2=CC=C(OC)C(OC)=C2)=O)SC3=C1CCCC3)N |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TCS 359 是一种 2-酰基氨基噻吩-3-甲酰胺，是一种有效的选择性FLT3抑制剂，IC50为 42 nM。TCS 359 抑制 MV4-11 细胞增殖，IC50为 340 nM。 |
| IC50和靶点: | |
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Grafone, T., Palmisano, M., Nicci, C., et al.An overview on the role of FLT3-tyrosine kinase receptor in acute myeloid leukemia: Biology and treatmentOncol.Rev.6(1),64-74(2012)
Lyman, S.D., and Jacobsen, S.E.W.c-kit ligand and Flt3 ligand: Stem/progenitor cell factors with overlapping yet distinct activitiesBlood91(4),1101-1134(1998)
Patch, R.J., Baumann, C.A., Liu, J., et al.Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3Bioorg. Med. Chem. Lett.16(12),3282-3286(2006)
Bennett, C.A., Winters, A.C., Barretti, N.N., et al.Molecular targeting of MLL-rearranged leukemia cell lines with the synthetic peptide PFWT synergistically enhances the cytotoxic effect of established chemotherapeutic agentsLeuk. Res.33(7),937-947(2009)
