AMG 925
Cat. No.：YN440351
CAS No. ：1401033-86-0
规格
价格(RMB)
库存
| 产品名称: | AMG 925 |
| CAS No.: | 1401033-86-0 |
| Chemical Name: | 1-[7,8-dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxy-ethanone |
| Synonyms: | AMG 925;1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone;AMG-925;AMG925;RB6Y814V4I;2-hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrr |
| 分子量: | 471.55 |
| 分子式: | C₂₆H₂₉N₇O₂ |
| SMILES: | OCC(N1CC2=C(N=C(NC3=NC=C4C(N([C@H]5CC[C@H](C)CC5)C6=CN=CC=C64)=N3)C=C2)CC1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AMG 925 是一种有效的选择性的FLT3/CDK4双重抑制剂，IC50分别为 2±1 nM 和 3±1 nM。 |
| IC50和靶点: | [{name:"FLT3:2 nM (IC50)"},{name: "CDK4:3 nM (IC50)"},{name: "CDK6:8 nM (IC50)"},{name: "CDK2:375 nM (IC50)"},{name: "CDK1:1.9 μM (IC50)"}] |
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Li, Z., Wang, X., Eksterowicz, J., et al.Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3J. Med. Chem.57(8),3430-3439(2014)
