Edoxaban
Cat. No.：YN370245
CAS No. ：480449-70-5
| 产品名称: | Edoxaban |
| CAS No.: | 480449-70-5 |
| Chemical Name: | N-(5-Chloro-2-pyridinyl)-N'-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl]-ethanediamide; DU 176; N-(5-Chloropyridin-2-yl)-N'-[(1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-[[(5-me |
| Synonyms: | 依度沙班; DU-176 |
| 分子量: | 548.06 |
| 分子式: | C₂₄H₃₀ClN₇O₄S |
| SMILES: | O=C(N(C)C)[C@@H](CC1)C[C@H]([C@H]1NC(C(NC(C=C2)=NC=C2Cl)=O)=O)NC(C3=NC(CC4)=C(CN4C)S3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Edoxaban (DU-176) 是一种选择性，有效和口服活性的factor Xa (FXa)抑制剂，对游离FXa和凝血酶原的Ki分别为 0.561 nM 和 2.98 nM。Edoxaban 是一种抗凝剂，可用于预防中风。Edoxaban 还是一种凝血酶和凝血因子 IXaβ (FIXa) 的弱抑制剂，Ki值分别为 6.00 μM 和 41.7 μM，对FXa的选择性超过 10000 倍。Edoxaban 具有抗血栓形成的特性，可用于血栓栓塞性疾病的研究。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Ruff, C., et al.: Am. Heart J., 160, 635 (2010)
Ogata, K., et al.: J. Clin. Pharm., 50, 73 (2010)
