Edoxaban tosylate monohydrate
Cat. No.：YN370246
CAS No. ：1229194-11-9
| 产品名称: | Edoxaban tosylate monohydrate |
| CAS No.: | 1229194-11-9 |
| Chemical Name: | LIXIANA; N-(5-Chloropyridin-2-yl)-N'-((1S,2R,4S)-4-[(dimethyl amino)carbonyl]-2-[[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino]cyclohexyl)ethanediamide p-Toluenesulfonate hydrate |
| Synonyms: | DU-176b monohydrate |
| 分子量: | 738.27 |
| 分子式: | C₃₁H₄₀ClN₇O₈S₂ |
| SMILES: | O=C(N(C)C)[C@@H](CC1)C[C@H]([C@H]1NC(C(NC(C=C2)=NC=C2Cl)=O)=O)NC(C3=NC(CC4)=C(CN4C)S3)=O.O=S(C5=CC=C(C)C=C5)(O)=O.O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Edoxaban tosylate monohydrate (DU-176b monohydrate) 是一种选择性，有效和口服活性的factor Xa (FXa)抑制剂，对游离FXa和凝血酶原的Ki分别为 0.561 nM 和 2.98 nM。Edoxaban tosylate monohydrate 是一种抗凝剂，可用于预防中风。Edoxaban tosylate 还是一种凝血酶和凝血因子 IXaβ (FIXa) 的弱抑制剂，Ki值分别为 6.00 μM 和 41.7 μM，对FXa的选择性超过 10 |
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| Solvent & Solubility: |
Ruff, C., et al.: Am. Heart J., 160, 635 (2010)
Ogata, K., et al.: J. Clin. Pharm., 50, 73 (2010)
