Apixaban
Cat. No.：YN372637
CAS No. ：503612-47-3
| 产品名称: | Apixaban |
| CAS No.: | 503612-47-3 |
| Chemical Name: | 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-pyrazolo[3,4-c]pyridine-3-carboxamide |
| Synonyms: | 阿哌沙班; BMS-562247-01 |
| 分子量: | 459.50 |
| 分子式: | C₂₅H₂₅N₅O₄ |
| SMILES: | NC(C1=NN(C2=C1CCN(C2=O)C3=CC=C(C=C3)N4CCCCC4=O)C5=CC=C(C=C5)OC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Apixaban (BMS-562247-01) 是一种高度选择性，可逆并具有口服活性的凝血因子 Xa (Factor Xa) 抑制剂，抑制人和兔凝血因子 Xa 的Ki值分别为 0.08 nM 和 0.17 nM。Apixaban 可以用于各种血栓栓塞疾病的相关研究。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Turpie, A.G.G.Oral, direct factor Xa inhibitors in development for the prevention and treatment of thromboembolic diseasesArterioscler. Thromb. Vasc. Biol.27(6),1238-1247(2007)
Lester, P.A., Coleman, D.M., Diaz, J.A., et al.Apixaban versus warfarin for mechanical heart valve thromboprophylaxis in a swine aortic heterotopic valve modelArterioscler. Thromb. Vasc. Biol.37(5),942-948(2017)
