S63845
Cat. No.：YN270017
CAS No. ：1799633-27-4
| 产品名称: | S63845 |
| CAS No.: | 1799633-27-4 |
| Chemical Name: | α(R)-[[(5S)-5-[3-chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(5-fluoro-2-furanyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]methoxy]-benzenepropanoic acid |
| Synonyms: | S 63845,S-63845 |
| 分子量: | 829.26 |
| 分子式: | C₃₉H₃₇ClF₄N₆O₆S |
| SMILES: | CC(C(Cl)=C(OCCN1CCN(C)CC1)C=C2)=[C@@]2[C@]3=C(C4=CC=C(F)O4)SC5=NC=NC(O[C@H](CC6=C(OCC7=CC=NN7CC(F)(F)F)C=CC=C6)C(O)=O)=C53 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | S63845 是一种有效的选择性骨髓细胞白血病 1 (MCL1) 抑制剂，结合人MCL1的Kd值为 0.19 nM。 |
| IC50和靶点: | [{name:"MCL1:0.19 nM (Kd)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Kotschy, A., Szlavik, Z., Murray, J., et al.The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer modelsNature538(7626),477-482(2016)
