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TCPOBOP

Cat. No.:YN270049

  • CAS No. :76150-91-9

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    • 参考文献
    • 产品名称: TCPOBOP
      CAS No.: 76150-91-9
      Chemical Name: 2,2'-[1,4-phenylenebis(oxy)]bis[3,5-dichloro]-pyridine
      Synonyms:TCPOBOP
      分子量:402.06
      分子式:C₁₆H₈Cl₄N₂O₂
      SMILES:ClC1=CN=C(OC2=CC=C(OC3=NC=C(Cl)C=C3Cl)C=C2)C(Cl)=C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: TCPOBOP 是一种组成型雄甾烷受体 (CAR)激动剂,可诱导强健的肝细胞增殖和肝肿大,无任何肝损伤或组织缺失。TCPOBOP 通过改变Bcl-2蛋白减弱 Fas 诱导的小鼠肝损伤。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
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    • Choi, H.S., Chung, M., Tzameli, I., et al.Differential transactivation by two isoforms of the orphan nuclear hormone receptor CARJ. Biol. Chem.272(38),23565-23571(1997)

      Tzameli, I., Pissios, P., Schuetz, E.G., et al.The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CARMol. Cell. Biol.20(9),2951-2958(2000)

      Timsit, Y.E., and Negishi, M.CAR and PXR: The xenobiotic-sensing receptorsSteroids72(3),231-246(2007)

      Smith, G., Henderson, C.J., Parker, M.G., et al.1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, an extremely potent modulator of mouse hepatic cytochrome P-450 gene expressionBiochem. J.289(Pt 3),807-813(1993)

      Wang, X., Sykes, D.B., and Miller, D.S.Constitutive androstane receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrierMol. Pharmacol.78(3),376-383(2010)

      Maher, J.M., Cheng, X., Slitt, A.L., et al.Induction of the multidrug resistance-associated protein family of transporters by chemical activators of receptor-mediated pathways in mouse liverDrug Metab. Dispos.33(7),956-962(2005)

      Kakizaki, S., Karami, S., and Negishi, M.Retinoic acids repress constitutive active receptor-mediated induction by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene of the CYP2B10 gene in mouse primary hepatocytesDrug Metab. Dispos.30(2),208-211(2002)

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    • C1
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      C2
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