BT2
Cat. No.：YN270130
| 产品名称: | BT2 |
| CAS No.: | 34576-94-8 |
| Chemical Name: | 3,6-dichloro-benzo[b]thiophene-2-carboxylic acid |
| Synonyms: | 3,6-二氯-2-苯并噻吩羧酸 |
| 分子量: | 247.10 |
| 分子式: | C₉H₄Cl₂O₂S |
| SMILES: | O=C(O)C1=C(C2=CC=C(C=C2S1)Cl)Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BT2 是 BCKDC 激酶 (BDK) 抑制剂，IC50值为 3.19 μM。BT2 与BDK的结合会触发支链 α-酮酸脱氢酶复合物 (BCKDC) 的 N 末端结构域的螺旋运动，从而导致BDK与 BCKDC 分离。BT2 (compound 4) 也是一种有效的选择性的Mcl-1抑制剂，Ki值为 59 μM。 |
| IC50和靶点: | [{name:"BDK:3.19 μM (IC50)"},{name: "Mcl-1:59 μM (Ki)"}] |
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| Solvent & Solubility: |
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Cheng, K., Wang, X., and Yin, H.Small-molecule inhibitors of the TLR3/dsRNA complexJ. Am. Chem. Soc.133(11),3764-3767(2011)
Katane, M., Osaka, N., Matsuda, S., et al.Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitroJ. Med. Chem.56(5),1894-1907(2013)
