TW-37
Cat. No.：YN270139
| 产品名称: | TW-37 |
| CAS No.: | 877877-35-5 |
| Chemical Name: | N-[4-[[2-(1,1-dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]-benzamide |
| Synonyms: | TW 37 |
| 分子量: | 573.70 |
| 分子式: | C₃₃H₃₅NO₆S |
| SMILES: | O=C(C1=CC(CC2=CC=CC=C2C(C)C)=C(C(O)=C1O)O)NC3=CC=C(C=C3)S(=O)(C4=CC=CC=C4C(C)(C)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TW-37 是一种有效的Bcl-2抑制剂，作用于Mcl-1，Bcl-2和Bcl-xL，Ki值分别为 260，290 和 1110 nM。 |
| IC50和靶点: | [{name:"Mcl-1:260 nM (Ki)"},{name: "Bcl-2:290 nM (Ki)"},{name: "Bcl-xL:1110 nM (Ki)"}] |
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Verhaegen, M., Bauer, J.A., de la Vega, C.M., et al.A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen speciesCancer Res.66(23),11348-11359(2006)
Zeitlin, B.D., Joo, E., Dong, Z., et al.Antiangiogenic effect of TW37, a small-molecule inhibitor of Bcl-2Cancer Res.66(17),8698-8706(2006)
Azmi, A.S., and Mohammad, R.M.Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapyJ. Cell Physiol.218(1),13-21(2009)
