Gossypol
Cat. No.：YN270224
| 产品名称: | Gossypol |
| CAS No.: | 303-45-7 |
| Chemical Name: | 1,1’,6,6’,7,7’-hexahydroxy-3,3’-dimethyl-5,5’-bis(1-methylethyl)-[2,2’-binaphthalene]-8,8’-dicarboxaldehyde |
| Synonyms: | 棉酚; BL 193 |
| 分子量: | 518.55 |
| 分子式: | C₃₀H₃₀O₈ |
| SMILES: | O=CC1=C(O)C(O)=C(C(C)C)C2=CC(C)=C(C3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O)C(O)=C12 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Gossypol 是一种从棉籽和根中分离出来的天然产物，分别与Bcl-xL蛋白和Bcl-2蛋白结合，Ki值分别为 0.5-0.6 μM 和 0.2-0.3 mM。 |
| IC50和靶点: | [{name:"Bcl-xL:0.5-0.6 μM (Ki)"},{name: "Bcl-2:0.2-0.3 mM (Ki)"}] |
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Coutinho, E.M.Gossypol: A contraceptive for menContraception65(4),259-263(2002)
Royer, R.E., Deck, L.M., Campos, N.M., et al.Biologically active derivatives of gossypol: Synthesis and antimalarial activities of peri-acylated gossylic nitrilesJ. Med. Chem.29(9),1799-1801(1986)
Deck, L.M., Vander Jagt, D.L., and Royer, R.E.Gossypol and derivatives: A new class of aldose reductase inhibitorsJ. Med. Chem.34(11),3301-3305(1991)
Yan, F., Cao, X.X., Jiang, H.X., et al.A novel water-soluble gossypol derivative increases chemotherapeutic sensitivity and promotes growth inhibition in colon cancerJ. Med. Chem.53(15),5502-5510(2010)
