Sabutoclax
Cat. No.：YN270298
| 产品名称: | Sabutoclax |
| CAS No.: | 1228108-65-3 |
| Chemical Name: | (1R)-1,1′,6,6′,7,7′-hexahydroxy-3,3′-dimethyl-N5,N5'-bis[(2R)-2-phenylpropyl]-[2,2′-binaphthalene]-5,5′-dicarboxamide |
| Synonyms: | BI-97C1 |
| 分子量: | 700.78 |
| 分子式: | C₄₂H₄₀N₂O₈ |
| SMILES: | O=C(C1=C(O)C(O)=CC2=C(O)[C@@]([C@@]3=C(C)C=C4C(C(NC[C@@H](C5=CC=CC=C5)C)=O)=C(O)C(O)=CC4=C3O)=C(C)C=C12)NC[C@@H](C6=CC=CC=C6)C.[R] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sabutoclax 是有效的和有选择性的Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1)抑制剂，IC50值分别为 0.32 μM， 0.31 μM， 0.20 μM， 0.62 μM。 |
| IC50和靶点: | [{name:"Bcl-xL:0.31 μM (IC50)"},{name: "BCL2:0.32 μM (IC50)"},{name: "Mcl-1:0.2 μM (IC50)"},{name: "Bfl-1:0.62 μM (IC50)"}] |
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| Solvent & Solubility: |
Wei, J., Stebbins, J.L., Kitada, S., et al.BI-97C1, an optically pure apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteinsJ. Med. Chem.53(10),4166-4176(2010)
