UMI-77
Cat. No.：YN270369
CAS No. ：518303-20-3
| 产品名称: | UMI-77 |
| CAS No.: | 518303-20-3 |
| Chemical Name: | 2-[[4-[[(4-bromophenyl)sulfonyl]amino]-1-hydroxy-2-naphthalenyl]thio]-acetic acid |
| Synonyms: | UMI77,UMI 77 |
| 分子量: | 468.34 |
| 分子式: | C₁₈H₁₄BrNO₅S₂ |
| SMILES: | O=C(O)CSC1=CC(NS(=O)(C2=CC=C(Br)C=C2)=O)=C3C=CC=CC3=C1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | UMI-77是一种选择性的Mcl-1抑制剂，对Mcl-1具有高亲和力 (IC50= 0.31 μM)。UMI-77 结到Mcl-1的 BH3 结合沟，Ki值为 490 nM，比作用于 Bcl-2 家族其他成员的选择性高。 |
| IC50和靶点: | [{name:"Mcl-1:0.49 μM (Ki)"},{name: "Bfl-1:5.33 μM (Ki)"},{name: "Bcl-W:8.19 μM (Ki)"},{name: "Bcl-2:23.83 μM (Ki)"},{name: "Bcl-xL:32.99 μM (Ki)"}] |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Abulwerdi, F., Liao, C., Liu, M., et al.A novel small-molecule inhibitor of mcl-1 blocks pancreatic cancer growth in vitro and in vivoMol. Cancer Ther.13(3),565-575(2014)
