A-1155463
Cat. No.：YN270386
CAS No. ：1235034-55-5
| 产品名称: | A-1155463 |
| CAS No.: | 1235034-55-5 |
| Chemical Name: | 2-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-4-thiazolecarboxylic acid |
| Synonyms: | A 1155463,醋酸艾塞那肽,A1155463 |
| 分子量: | 669.79 |
| 分子式: | C₃₅H₃₂FN₅O₄S₂ |
| SMILES: | O=C(C1=C(CCCOC2=CC=C(C#CCN(C)C)C=C2F)SC(N3CC4=C(C=CC=C4C(NC5=NC6=CC=CC=C6S5)=O)CC3)=N1)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | A-1155463是高效选择性的BCL-XL抑制剂，在Molt-4细胞中的EC50值为70 nM。 |
| IC50和靶点: | [{name:"Bcl-xL:0.01 nM (Ki)"},{name: "Bcl-2:80 nM (Ki)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Tao, Z.-F., Hasvold, L., Wang, L., et al.Discovery of a potent and selective BCL-XL inhibitor with in vivo activityACS Med. Chem. Lett.5(10),1088-1093(2014)
Bulanova, D., Ianevski, A., Bugai, A., et al.Antiviral properties of chemical inhibitors of cellular anti-apoptotic Bcl-2 proteinsViruses9(10),E271(2017)
