ABT-737
Cat. No.：YN270404
CAS No. ：852808-04-9
| 产品名称: | ABT-737 |
| CAS No.: | 852808-04-9 |
| Chemical Name: | 4-[4-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-benzamide |
| Synonyms: | ABT-737;4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide;ABT 737;4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethyla |
| 分子量: | 813.43 |
| 分子式: | C₄₂H₄₅ClN₆O₅S₂ |
| SMILES: | CN(CC[C@@H](NC1=CC=C(C=C1[N+]([O-])=O)S(NC(C2=CC=C(C=C2)N3CCN(CC3)CC4=CC=CC=C4C5=CC=C(C=C5)Cl)=O)(=O)=O)CSC6=CC=CC=C6)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ABT-737 是一种类似 BH3 的Bcl-2，Bcl-xL，和Bcl-w的抑制剂，EC50值分别为 30.3 nM，78.7 nM 和 197.8 nM。 |
| IC50和靶点: | [{name:"Bcl-2:30.3 nM (EC50)"},{name: "Bcl-xL:78.7 nM (EC50)"},{name: "Bcl-W:197.8 nM (EC50)"},{name: "Bcl-B:1820 nM (EC50)"},{name: "Bfl-1:>10 μM (EC50)"},{name: "Mcl-1:>10 μM (EC50)"}] |
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| Solvent & Solubility: |
Ni Chonghaile, T., and Letai, A.Mimicking the BH3 domain to kill cancer cellsOncogene27(Suppl 1),S149-S157(2008)
Oltersdorf, T., Elmore, S.W., Shoemaker, A.R., et al.An inhibitor of Bcl-2 family proteins induces regression of solid tumoursNature435(7042),677-681(2005)
Bruncko, M., Oost, T.K., Belli, B.A., et al.Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xLJ. Med. Chem.50(4),641-662(2007)
Trudel, S., Stewart, A.K., Li, Z., et al.The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalanClin. Cancer Res.13(2),621-629(2007)
Konopleva, M., Watt, J., Contractor, R., et al.Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax)Cancer Res.68(9),3413-3420(2008)
