Gambogic Acid
Cat. No.：YN270441
| 产品名称: | Gambogic Acid |
| CAS No.: | 2752-65-0 |
| Chemical Name: | 2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2Z-butenoic acid |
| Synonyms: | 藤黄酸; Beta-Guttiferrin |
| 分子量: | 628.75 |
| 分子式: | C₃₈H₄₄O₈ |
| SMILES: | O=C(O)/C(C)=C\C[C@@]1(C2=O)OC(C)(C)[C@@](C[C@@]2([H])C=C34)([H])[C@]31OC5=C(C(O)=C(C=C[C@](CC/C=C(C)/C)(C)O6)C6=C5C/C=C(C)\C)C4=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Gambogic Acid (Beta-Guttiferrin) 来自Garcinia hanburyi树的藤黄树脂。Gambogic Acid (Beta-Guttiferrin) 抑制Bcl-XL，Bcl-2，Bcl-W，Bcl-B，Bfl-1和Mcl-1，IC50分别为 1.47 μM，1.21 μM，2.02 μM，0.66 μM，1.06 μM 和 0.79 μM。 |
| IC50和靶点: | [{name:"Bcl-B:0.66 μM (IC50)"},{name: "Mcl-1:0.79 μM (IC50)"},{name: "Bfl-1:1.06 μM (IC50)"},{name: "Bcl-2:1.21 μM (IC50)"},{name: "Bcl-xL:1.47 μM (IC50)"},{name: "Bcl-W:2.02 μM (IC50)'}, 'Autophagy'] |
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Hoch, D.G., Abegg, D., Hannich, J.T., et al.Combined omics approach identifies gambogic acid and related xanthones as covalent inhibitors of the serine palmitoyltransferase complexCell Chem. Bio.27(5),586-597(2020)
Kasibhatla, S., Jessen, K.A., Maliartchouk, S., et al.A role for transferrin receptor in triggering apoptosis when targeted with gambogic acidProc. Natl. Acad. Sci. USA102(34),12095-12100(2005)
He, X.y., Liu, X.j., Chen, X., et al.Gambogic acid induces EGFR degradation and Akt/mTORC1 inhibition through AMPK dependent-LRIG1 upregulation in cultured U87 glioma cellsBiochem. Biophys. Res. Commun.435(3),397-402(2013)
Zhang, H.Z., Kasibhatla, S., Wang, Y., et al.Discovery, characterization and SAR of gambogic acid as a potent apoptosis inducer by a HTS assayBioorg. Med. Chem.12(2),309-317(2004)
Zhai, D., Jin, C., Shiau, C.W., et al.Gambogic acid is an antagonist of anti-apoptotic Bcl-2-family proteinsMol. Cancer Ther.7(6),1639-1646(2008)
Zhao, L., Guo, Q.L., You, Q.D., et al.Gambogic acid induces apoptosis and regulates expressions of Bax and Bcl-2 protein in human gastric carcinoma MGC-803 cellsBiol. Pharm. Bull.27(7),998-1003(2004)
Felth, J., Lesiak-Mieczkowska, K., D'Arcy, P., et al.Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome systemInvest. New Drugs31(3),587-598(2013)
Zaks-Makhina, E., Li, H., Grishin, A., et al.Specific and slow inhibition of the Kir2.1 K+ channel by gambogic acidJ. Biol. Chem.284(23),15432-15438(2009)
