PD146176
Cat. No.：YN270048
CAS No. ：4079-26-9
| 产品名称: | PD146176 |
| CAS No.: | 4079-26-9 |
| Chemical Name: | 6,11-dihydro-[1]benzothiopyrano[4,3-b]indole |
| Synonyms: | NSC168807 |
| 分子量: | 237.32 |
| 分子式: | C₁₅H₁₁NS |
| SMILES: | C1(N2)=C(CSC3=CC=CC=C31)C4=C2C=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PD146176 (NSC168807) 是一种 15-脂氧合酶(15-LO)抑制剂，对兔网织红细胞 15-LO 有抑制作用 (Ki=197 nM,IC50=0.54 μM)。PD146176 通过刺激老年三重转基因小鼠的自噬作用逆转认知障碍、脑淀粉样变性和 tau 病理学。 |
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Bocan, T.M.A., Rosebury, W.S., Mueller, S.B., et al.A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbitAtherosclerosis136,203-216(1998)
Sendobry, S.M., Cornicelli, J.A., Welch, K., et al.Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant propertiesBr. J. Pharmacol.120,1199-1206(1997)
Sordillo, L.M., Weaver, J.A., Cao, Y.Z., et al.Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cellsProstaglandins Other Lipid Mediat.76,19-34(2005)
Succol, F., and Praticò, D.A role for 12/15 lipoxygenase in the amyloid ß precursor protein metabolismJ. Neurochem.103,380-387(2007)
