Imidazole ketone erastin
Cat. No.：YN270128
CAS No. ：1801530-11-9
| 产品名称: | Imidazole ketone erastin |
| CAS No.: | 1801530-11-9 |
| Chemical Name: | 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[5-[2-(1H-imidazol-1-yl)acetyl]-2-(1-methylethoxy)phenyl]-4(3H)-quinazolinone |
| Synonyms: | IKE |
| 分子量: | 655.14 |
| 分子式: | C₃₅H₃₅ClN₆O₅ |
| SMILES: | O=C1N(C2=CC(C(CN3C=CN=C3)=O)=CC=C2OC(C)C)C(CN4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)=NC6=CC=CC=C61 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Imidazole ketone erastin 是一种有效的，选择性的，代谢稳定的胱氨酸-谷氨酸逆转运蛋白，system xc-抑制剂和 ferroptosis 活化剂。Imidazole ketone erastin 具有抗肿瘤活性。 |
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Zhang, Y., Tan, H., Daniels, J.D., et al.Imidazole ketone erastin induces ferroptosis and slows tumor growth in a mouse lymphoma modelCell Chem. Biol.26(5),623-633(2019)
Larraufie, M.-H., Yang, W.S., Jiang, E., et al.Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubilityBioorg. Med. Chem. Lett.25(21),4787-4792(2015)
