Pioglitazone
Cat. No.：YN270277
| 产品名称: | Pioglitazone |
| CAS No.: | 111025-46-8 |
| Chemical Name: | 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione |
| Synonyms: | 吡格列酮; U 72107 |
| 分子量: | 356.44 |
| 分子式: | C₁₉H₂₀N₂O₃S |
| SMILES: | O=C(N1)SC(CC2=CC=C(OCCC3=NC=C(CC)C=C3)C=C2)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pioglitazone (U 72107) 是一种有效的选择性PPARγ激动剂，高亲和力结合到 PPARγ 配体结合域。作用于人和鼠 PPARγ，EC50分别为 0.93 和 0.99 μM。 |
| IC50和靶点: | [{name:"hPPARγ:0.93 μM (EC50)"},{name: "mouse PPARγ:0.99 μM (EC50)"},{name: "hPPARδ:43 μM (EC50)"},{name: "hPPARα:100 μM (EC50)"},{name: "mouse PPARα:100 μM (EC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Sakamoto, J., Kimura, H., Moriyama, S., et al.Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazoneBiochem. Biophys. Res. Commun.278(3),704-711(2000)
Willson, T.M., Brown, P.J., Sternbach, D.D., et al.The PPARs: From orphan receptors to drug discoveryJ. Med. Chem.43(4),527-550(2000)
Shannon, C.E., Daniele, G., Galindo, C., et al.Pioglitazone inhibits mitochondrial pyruvate metabolism and glucose production in hepatocytesFEBS J.284(3),451-465(2017)
Sugiyama, Y., Taketomi, S., Shimura, Y., et al.Effects of pioglitazone on glucose and lipid metabolism in Wistar fatty ratsArzneimittelforschung.40(3),263-267(1990)
Suzuki, S., Mori, Y., Nagano, A., et al.Pioglitazone, a peroxisome proliferator-activated receptor γ agonist, suppresses rat prostate carcinogenesisInt. J. Mol. Sci.17(12),pii: E2071(2016)
Zhao, Q., Wu, X., Yan, S., et al.The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypesJ. Neuroinflammation13(1),259(2016)
