Pifithrin-β hydrobromide
Cat. No.：YN270352
| 产品名称: | Pifithrin-β hydrobromide |
| CAS No.: | 511296-88-1 |
| Chemical Name: | 5,6,7,8-tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole, monohydrobromide |
| Synonyms: | PFT β hydrobromide |
| 分子量: | 349.29 |
| 分子式: | C₁₆H₁₇BrN₂S |
| SMILES: | CC1=CC=C(C2=CN3C(SC4=C3CCCC4)=N2)C=C1.Br |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pifithrin-β hydrobromide (PFT β hydrobromide) 是有效地p53抑制剂，IC50值为23 μM。 |
| IC50和靶点: | |
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Walton, M.I., Wilson, S.C., Hardcastle, I.R., et al.An evaluation of the ability of pifithrin-α and -β to inhibit p53 function in two wild-type p53 human tumor cell linesMol. Cancer Ther.4(9),1369-1377(2005)
Christodoulou, M.S., Colombo, F., Passarella, D., et al.Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitorsBioorg. Med. Chem.19(5),1649-1657(2011)
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Zuco, V., and Zunino, F.Cyclic pifithrin-α sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosisNeoplasia10(6),587-596(2008)
Kadekaro, A.L., Chen, J., Yang, J., et al.Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytesMol. Cancer Res.10(6),778-786(2012)
