Cisplatin
Cat. No.：YN270357
| 产品名称: | Cisplatin |
| CAS No.: | 15663-27-1 |
| Chemical Name: | (SP-4-2)-diamminedichloro-platinum |
| Synonyms: | 顺铂; CDDP; cis-Diaminodichloroplatinum |
| 分子量: | 300.05 |
| 分子式: | Cl₂H₆N₂Pt |
| SMILES: | Cl[Pt](Cl)([NH3])[NH3] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cisplatin (CDDP) 是一种抗肿瘤的化疗剂，它与DNA交联引起癌细胞中 DNA 损伤。Cisplatin 可激活铁死亡 (ferroptosis) 并诱导自噬 (autophagy)。 |
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Schmitt, S.M., Frezza, M., and Dou, Q.P.New applications of old metal-binding drugs in the treatment of human cancerFront. Biosci. (Schol. Ed.)4,375-391(2012)
Bose, R.N.Biomolecular targets for platinum antitumor drugsMini. Rev. Med. Chem.2(2),103-111(2002)
Takahashi, K., Ebihara, K., Honda, Y., et al.Antitumor activity of cis-dichlorodiammineplatinum(II) and its effect on cell cycle progressionGan To Kagaku Ryoho.9(4),624-631(1982)
Wennerberg, J., Alm, P., Biörklund, A., et al.Cell cycle perturbations in heterotransplanted squamous-cell carcinoma of the head and neck after mitomycin C and Cisplatin treatmentInt. J. Cancer.33(2),213-222(1984)
Zhang, L., Zheng, Y., Callahan, B., et al.Cisplatin inhibits protein splicing, suggesting inteins as therapeutic targets in mycobacteriaJ. Biol. Chem.286(2),1277-1282(2011)
