Idebenone
Cat. No.：YN270457
CAS No. ：58186-27-9
| 产品名称: | Idebenone |
| CAS No.: | 58186-27-9 |
| Chemical Name: | 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione |
| Synonyms: | 艾地苯醌 |
| 分子量: | 338.44 |
| 分子式: | C₁₉H₃₀O₅ |
| SMILES: | O=C1C(CCCCCCCCCCO)=C(C)C(C(OC)=C1OC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Idebenone是合成的辅酶Q10的变体，最初用于阿尔茨海默症和其它的认知缺陷。 |
| IC50和靶点: | |
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Crane, F.L.Biochemical functions of coenzyme Q10J. Am. Coll. Nutr.20(6),591-598(2001)
Suno, M., and Nagaoka, A.Inhibition of lipid peroxidation by a novel compound, idebenone (CV-2619)Jpn. J. Pharmacol.35(2),196-198(1984)
Arce, P.M., Goldschmidt, R., Khdour, O.M., et al.Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotectionBioorg. Med. Chem.20(17),5188-5201(2012)
Erb, M., Hoffman-Enger, B., Deppe, H., et al.Features of idebenone and related short-chain quinones that rescue ATP levels under conditions of impaired mitochondrial complex IPLoS One7(4),e36153(2012)
Heitz, F.D., Erb, M., Anklin, C., et al.Idebenone protects against retinal damage and loss of vision in a mouse model of Leber's hereditary optic neuropathyPLoS One7(9),e45182(2012)
Liu, J., and Wang, L.N.Mitochondrial enhancement for neurodegenerative movement disorders: A systematic review of trials involving creatine, coenzyme q10, idebenone and mitoquinoneCNS Drugs28(1),63-68(2014)
Tsou, A.Y., Friendman, L.A., Wilson, R.B., et al.Pharmacotherapy for Friedreich ataxiaCNS Drugs23(3),213-223(2009)
