ML162
Cat. No.：YN270630
CAS No. ：1035072-16-2
| 产品名称: | ML162 |
| CAS No.: | 1035072-16-2 |
| Chemical Name: | α-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiopheneacetamide |
| Synonyms: | ML-162;ML 162;ML162 |
| 分子量: | 477.4 |
| 分子式: | C23H22Cl2N2O3S |
| SMILES: | O=C(C(N(C(CCl)=O)C1=CC=C(OC)C(Cl)=C1)C2=CC=CS2)NCCC3=CC=CC=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ML162 是一种共价谷胱甘肽过氧化物酶 4 (GPX4) 抑制剂。ML162 对表达突变RAS癌基因的细胞系具有选择性的致死作用。 |
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Beatty, A., Singh, T., Tyurina, Y.Y., et al.Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1Nat. Commun.12(1),2244(2021)
Weïwer, M., Bittker, J.A., Lewis, T.A., et al.Development of small-molecule probes that selectively kill cells induced to express mutant RASBioorg. Med. Chem. Lett.22(4),1822-1826(2012)
