PF-4989216
Cat. No.：YN270632
CAS No. ：1055412-47-9
| 产品名称: | PF-4989216 |
| CAS No.: | 1055412-47-9 |
| Chemical Name: | (3Z)-5-chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one |
| Synonyms: | Chloro-SU5416, Chloro-Semaxanib |
| 分子量: | 272.7 |
| 分子式: | C15H13ClN2O |
| SMILES: | ClC1=CC=C2C(/C(C(N2)=O)=C/C3=C(C)C=C(C)N3)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (Z)-SU5614 是一种有效的FLT3抑制剂，在表达组成性激活的FLT3的 Ba/F3 和 AML 细胞系中选择性诱导生长停滞、凋亡和细胞周期停滞。 |
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| Solvent & Solubility: |
Spiekermann, K., Dirschinger, R.J., Schwab, R., et al.The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3Blood101(4),1494-1504(2003)
