Xevinapant hydrochloride
Cat. No.：YN270633
| 产品名称: | Xevinapant hydrochloride |
| CAS No.: | 1071992-57-8 |
| Chemical Name: | |
| Synonyms: | AT-406 hydrochloride; Debio 1143 hydrochloride; SM-406 hydrochloride |
| 分子量: | 412.9158 |
| 分子式: | C21H25N6OCl |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Xevinapant (AT-406) hydrochloride 是一种有效的、口服生物可利用的 Smac 模拟物，也是细胞凋亡蛋白(IAPs)抑制剂的拮抗剂。Xevinapant hydrochloride 与 XIAP、cIAP1 和 cIAP2 蛋白结合，Ki分别为 66.4、1.9 和 5.1 nM。Xevinapant hydrochloride 在无细胞功能测定中有效拮抗XIAPBIR3 蛋白，诱导细胞cIAP1蛋白的快速降解，并抑制各种人类癌细胞系中的癌细胞生长。Xevinapant hy |
| IC50和靶点: | [{name:"cIAP1:1.9 nM (Ki)"},{name: "cIAP2:5.1 nM (Ki)"},{name: "XIAP:66.4 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
