LCS3
Cat. No.：YN270635
CAS No. ：109844-92-0
| 产品名称: | LCS3 |
| CAS No.: | 109844-92-0 |
| Chemical Name: | N-(4-chlorophenyl)-5-nitro-2-furancarboxamide |
| Synonyms: | |
| 分子量: | 266.63706 |
| 分子式: | C11H7ClN2O4 |
| SMILES: | O=C(NC1=CC=C(Cl)C=C1)C=2OC(=CC2)N(=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LCS3 是可逆性和非竞争性的谷胱甘肽二硫化物还原酶 (GSR) 和硫氧还蛋白还原酶1 (TXNRD1) 抑制剂 (IC50分别为 3.3 µM 和 3.8 µM)。LCS3 表现出抗肿瘤活性，并诱导细胞凋亡，可用于肺腺癌 (LUAD) 的研究。 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Johnson, F.D., Ferrarone, J., Liu, A., et al.Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cellsCell Rep.38(6),110343(2022)
Gallardo-Marcias, R., Kumar, P., Jaskowski, M., et al.Optimization of N-benzyl-5-nitrofuran-2-carboxamide as an antitubercular agentBioorg. Med. Chem. Lett.29(4),601-606(2019)
