CIL56
Cat. No.：YN270644
CAS No. ：1213269-98-7
| 产品名称: | CIL56 |
| CAS No.: | 1213269-98-7 |
| Chemical Name: | 2-[(3R,6E,10E)-3-hydroxy-3,7,11,15-tetramethyl-6,10,14-hexadecatrien-1-yl]-3,5,6-trimethyl-2,5-cyclohexadiene-1,4-dione |
| Synonyms: | α-Tocotrienol quinone; PTC-743; Vatiquinone; NCT04378075 |
| 分子量: | 440.65786 |
| 分子式: | C29H44O3 |
| SMILES: | O=C1C(C)=C(C)C(C(CC[C@@](O)(C)CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)=C1C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) 是一种有效的细胞氧化应激保护剂，抑制细胞发生铁死亡 (ferroptosis)，可用于线粒体疾病的研究。EPI-743 是维生素 E 类似物，具有口服活性，可以通过影响细胞内谷胱甘肽的氧化还原状态来防止过量的 ROS 产生。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Shrader, W.D., Amagata, A., Barnes, A., et al.α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of agingBioorg. Med. Chem. Lett.21(12),3693-3698(2011)
Kahn-Kirby, A.H., Amagata, A., Maeder, C.I., et al.Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsyPLoS One14(3),e0214250(2019)
