CP-31398 dihydrochloride
Cat. No.：YN270645
CAS No. ：1217195-61-3
| 产品名称: | CP-31398 dihydrochloride |
| CAS No.: | 1217195-61-3 |
| Chemical Name: | N3-[2-[2-(4-methoxyphenyl)ethenyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine, dihydrochloride |
| Synonyms: | CP31398 dihydrochloride |
| 分子量: | 435.38948 |
| 分子式: | C22H26N4O • 2HCl |
| SMILES: | CN(C)CCCNC1=NC(/C=C/C2=CC=C(OC)C=C2)=NC3=C1C=CC=C3.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CP-31398 dihydrochloride 在 p53 突变或野生型的癌细胞中，稳定p53的活性构象、促进 p53 的活性。 |
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Foster, B.A., Coffey, H.A., Morin, M.J., et al.Pharmacological rescue of mutant p53 conformation and functionScience286(5449),2507-2510(1999)
Wischhusen, J., Naumann, U., Ohgaki, H., et al.CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell deathOncogene22(51),8233-8245(2003)
Rao, C.V., Patlolla, J.M., Qian, L., et al.Chemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J miceNeoplasia15(9),1018-1027(2013)
