Thalidomide-d
Cat. No.：YN270646
| 产品名称: | Thalidomide-d |
| CAS No.: | 1219177-18-0 |
| Chemical Name: | 2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione-4,5,6,7-d4 |
| Synonyms: | 沙利度胺 d |
| 分子量: | 262.25382 |
| 分子式: | C13H6D4N2O4 |
| SMILES: | O=C(C1=C2C([2H])=C([2H])C([2H])=C1[2H])N(C3C(NC(CC3)=O)=O)C2=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Thalidomide-d4是 Thalidomide 的氘代物。Thalidomide 最初是一种镇静剂，能够抑制cereblon(cullin-4 E3 泛素连接酶复合物 CUL4-RBX1-DDB1 的一部分)，Kd值约为 250 nM，具有免疫调节、抗炎、抗肿瘤作用。 |
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Faure, M., Thivolet, J., and Gaucherand, M.Inhibition of PMN leukocytes chemotaxis by thalidomideArch. Dermatol. Res.269(3),275-280(1980)
Haslett, P.A., Corral, L.G., Albert, M., et al.Thalidomide costimulates primary human T lymphocytes, preferentially inducing proliferation, cytokine production, and cytotoxic responses in the CD8+ subsetJ. Exp. Med.187(11),1885-1892(1998)
Davies, F.E., Raje, N., Hideshima, T., et al.Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myelomaBlood98(1),210-216(2001)
Tabata, C., Tabata, R., Kadokawa, Y., et al.Thalidomide prevents bleomycin-induced pulmonary fibrosis in miceJ. Immunol.179(1),708-714(2007)
Knobloch, J., Shaughnessy, J.D., Jr., and Rüther, U.Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathwayFASEB J.21(7),1410-1421(2007)
