UC2288
Cat. No.：YN270660
CAS No. ：1394011-91-6
| 产品名称: | UC2288 |
| CAS No.: | 1394011-91-6 |
| Chemical Name: | N-[4-chloro-3-(trifluoromethyl)phenyl]-N′-[trans-4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]cyclohexyl]-urea |
| Synonyms: | |
| 分子量: | 481.8190592 |
| 分子式: | C20H18ClF6N3O2 |
| SMILES: | FC(F)(F)C(C=N1)=CC=C1O[C@@H]2CC[C@H](CC2)NC(NC3=CC(C(F)(F)F)=C(C=C3)Cl)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | UC2288 是一种新型的、具有细胞通透性和口服活性的p21衰减试剂 (对 p21 具有相对选择性活性)，基于索拉非尼 (HY-10201) 的结构合成。UC2288 在不依赖 p53 的情况下下调 p21 mRNA 的表达，降低 p21 蛋白水平，对 p21 蛋白的稳定性影响很小。UC2288 对VEGFR2 和Raf激酶没有抑制作用，即使在 10 μM。 |
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Wettersten, H.I., Hwang, S.H., Li, C., et al.A novel p21 attenuator which is structurally related to sorafenibCancer Biol. Ther.14(3),278-285(2013)
Liang, R., and Zhu, X.UC2288 induces cell apoptosis of nasopharyngeal carcinoma cells via inhibiting EGFR/ERK pathwayJ. Cancer12(4),988-995(2021)
Gupta, R., Dong, Y., Solomon, P.D., et al.Synergistic tumor suppression by combined inhibition of telomerase and CDKN1AProc. Natl. Acad. Sci. USA111(30),E3062-E3071(2014)
